Which sign is commonly associated with PCP intoxication?

• A. Hypotension
• B. Nystagmus
• C. Hyperglycemia
• D. Paresthesias

Answer: (B)

Nystagmus is the sign most commonly linked to PCP intoxication. PCP (phencyclidine) is a dissociative anesthetic that blocks NMDA receptors, leading to perceptual changes, agitation, and impaired motor control. This disruption also affects the brain’s eye movement and vestibular systems, so involuntary eye movements—especially vertical nystagmus—are a characteristic clue when PCP exposure is suspected.

Other options don’t fit PCP as neatly: hypotension is not the typical pattern (PCP more often causes agitation with tachycardia and hypertension rather than low blood pressure), hyperglycemia is not a defining feature, and paresthesias aren’t a hallmark sign of PCP intoxication.