Disulfiram should not be used in patients with which liver condition?

• A. Cirrhosis
• B. Hepatitis
• C. Fatty liver
• D. Normal liver

Answer: (A)

Disulfiram is processed by the liver and can cause liver injury itself. In cirrhosis, the liver’s function is severely impaired, which reduces the ability to metabolize the drug and increases the risk of hepatotoxicity and severe adverse reactions if alcohol is consumed. For this reason, disulfiram is contraindicated in patients with cirrhosis. In contrast, while liver disease in general warrants caution, normal liver function is more compatible with its use, and patients with milder liver conditions may be considered only with careful evaluation. The core idea is that significant hepatic impairment, especially cirrhosis, makes disulfiram unsafe.